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Prolia (Denosumab)

Prolia (denosumab) is a biologic medicine used to treat and prevent thinning of the bones (called osteoporosis) and other diseases where loss of bone mass is a concern.

Prolia is a type of protein called a monoclonal antibody that works by disrupting a natural process in the body that breaks down the bones. This gives a different natural process that builds up the bones a chance to get ahead and build up bone density.

Taking Prolia

Prolia is available in a pre-filled syringe with a normal dose of 60 mg. It is taken once every 6 months by injection. The injection is usually given by a doctor or nurse.

To help build the bones, patients should take calcium and vitamin D while taking Prolia. Doctors will tell their patients the right amount of calcium and vitamin D to take. Patients should take any supplements exactly as prescribed by their doctor.

Important Tests and Risks

Doctors need to monitor the response of patients taking Prolia. This is done with a Bone Mineral Density test, usually once every 1 to 3 years.

Prolia can make it a bit harder to fight infections. Patients who develop a fever or think they have an infection are advised to tell their doctor.

Prolia been associated with a very rare problem with the jaw called osteonecrosis. This problem is sometimes seen after dental work. Patients should let their doctor know if they develop sudden pain in the jaw.

Alcohol is known to increase fracture risk by decreasing bone mineral density and promoting osteoperosis. Patients who are prescribed Prolia should stop drinking alcohol, or at least significantly reduce the amount of alcohol that they drink.

Drug Identification Number (DIN): 02343541 (Injection)